Goldfine AB, ME Patti, L Zuberi, BJ Goldstein, R LeBlanc, EJ Landaker, ZY Jiang, GR Willsky, CR Kahn. In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Goldfine AB, DC Simonson, F Folli, ME Patti, CR Kahn. Metabolic effects of vanadyl sulfate in humans with insulin-dependent and non insulin-dependent diabetes mellitus in vivo and in vitro studies. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin dependent diabetes mellitus. J Nutr 130: 715-718, 2000.Ĭohen N, M Halberstram, P Shilmovich, CJ Chang, H Sharnoon, L Rossetti. Mechanisms of chromium action: low-molecular weight-chromium-binding substance. Is chromium a trace essential metal? Biofactors 11: 149-162, 2000. The nutritional supplement chromium(III) tris(picolinate) cleaves DNA. Speetjens JK, RA Collins, JB Vincent, SA Wolski. Control of steroid-induced diabetes with supplemental chromium. Ravina A, L Slezak, N Mirsky, RA Anderson. Chromium supplementation for women with gestational diabetes. Isolation and characterization of a biologically active chromium oligopeptide from bovine liver. Chromium oligopeptide activates insulin receptor kinase activity. J Trace Elem Exp Med 12: 55-60, 1999.ĭavis CM, JB Vincent. Follow-up survey of people in China with type 2 diabetes consuming supplemental chromium. J Trace Elem Exp Med 12: 71-83, 1999.Ĭheng N, X Zhu, H Shi, W Wu, J Chi, J Cheng, RA Anderson. Effect of chromium picolinate on insulin sensitivity in vivo. Diabetes 46: 1786-1791, 1997.Ĭefalu WT, AD Bell-Farrow, J Stenger, ZQ Wang, T King, T Morgan, JG Terry. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. J Am Coll Nutr 16: 404-410, 1997.Īnderson RA, N Cheng, NA Bryden, MM Polansky, N Cheng, J Chi, J Feng. Nutritional factors influencing the glucose/insulin system: chromium. Thus, doses of these minerals that elicit beneficial effects are pharmacologic and not nutritional.Īnderson RA. Adverse effects of ingestion of these mineral supplements at these doses have been reported. The doses of supplemental vanadium far exceed the apparent human vanadium requirement (10 mcg/d) whereas the levels of chromium supplementation surpass the safe and adequate intake level for chromium (50 to 200 mcg/d). Also, chromium supplements, specifically chromium picolinate, in amounts of 400 to 1000 mcg/d ameliorate glucose metabolic abnormalities in some patients with insulin resistance or type 2 diabetes. Supplementation of diabetic patients with vanadium salts in doses ranging from 25 to 100 mg of elemental vanadium daily for up to six weeks elicits partial normalization of glucose metabolic irregularities. Since 1980, evidence has accumulated to show that vanadium salts, vanadyl and vanadate, mimic insulin action in isolated cell systems and produce glucose-lowering effects when given to animals with diabetes. Public interest in the use of supplemental vanadium and chromium to ameliorate the symptoms of diabetes is burgeoning because of their putative action as insulin potentiating agents. If you wish to comment on product selection, pricing, ordering, delivery or other issues, please contact our customer service.Lessons From Micronutrient Studies In Patients With Glucose Intolerance and Diabetes Mellitus: Chromium and Vanadium We reserve the right to remove non-compliant reviews language. Personal information such as email addresses, phone numbers or physical addressesĪll reviews are subject to our Terms of Use.Advertising, spam, references to other websites or retailers.Critical or inappropriate comments about other reviews and shoppers. Language referencing a state of disease (including but not limited to references to pain, aches, inflammation, medicine replacement, cancer, cold/flu, arthritis, depression, insomnia, etc.).To meet our publishing standards, please refrain from including the following in your review: Be sure to explain why you like or dislike the product and focus on the product's features. We value your input and look forward to hearing about your personal product experiences. Reviews containing references to a state of disease (e.g., pain, aches, inflammation, medicine replacement, cancer, cold/flu, arthritis, depression, insomnia, etc.) cannot be published.
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